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J Korean Med Assoc > Volume 54(6); 2011 > Article
Han and You: Wound coverage using advanced technology in Korea

Abstract

The purpose of this article is to outline a variety of wound coverage methods, so that general practitioners can modify their approach to wound healing and possibly incorporate this relevant information into their practice. The article starts with an update on the role of dressing materials in wound healing. It provides a balanced view of what is currently available in Korea. The use of dermal templates has helped in the coverage of wounds that in the past would have required complex surgical solutions. Growth factors and cell therapy provide many of the missing ingredients to jumpstart the wound so that it can go on to heal successfully. The negative pressure therapy, the hydrostatic pressure and/or ultrasonic therapy, and the hyperbaric oxygen therapy also help in healing wounds. Many of these products were introduced recently, and our understanding of how to use them with greater effectiveness has grown. According to the development of bioengineering techniques, advanced dressing materials, growth factors, cell therapy, etc has been introduced for clinical use. Using those materials, the wound coverage can more effective with better results.

References

1. Han SK. Management of diabetic wound 2008;Seoul: Kunja. 332.

2. Han SK, Yoon TH, Kim JB, Kim WK. Dermis graft for wound coverage. Plast Reconstr Surg 2007;120:166-172.

3. Han SK, Kim JB, Kim WK. Is the dermis graft a reliable and effective option for wound coverage? Reply Plast Reconstr Surg 2008;121:684-685.

4. Han SK, Kim HS, Kim WK. Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers. Dermatol Surg 2009;35:1342-1348.

5. Han SK, Choi KJ, Kim WK. Clinical application of fresh fibroblast allografts for the treatment of diabetic foot ulcers: a pilot study. Plast Reconstr Surg 2004;114:1783-1789.

6. Eum SJ, Han SK, Gu JH, Jeong SH, Kim WK. Treatment of diabetic ulcer using autologous fibroblast-hyaluronic acid complex. J Korean Soc Plast Reconstr Surg 2009;36:548-554.

7. Seo DL, Han SK, Chun KW, Kim WK. Clinical application of adipose derived stromal cell autograft for wound coverage. J Korean Soc Plast Reconstr Surg 2008;35:653-658.

8. Han SK, Kim HR, Kim WK. The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells: a pilot study. Wound Repair Regen 2010;18:342-348.

9. Han SK, Kim DW, Jeong SH, Hong YT, Woo HS, Kim WK, Gottrup F. Potential use of blood bank platelet concentrates to accelerate wound healing of diabetic ulcers. Ann Plast Surg 2007;59:532-537.

10. Jeong SH, Han SK, Kim WK. Treatment of diabetic foot ulcers using a blood bank platelet concentrate. Plast Reconstr Surg 2010;125:944-952.

11. Eum SJ, Han SK, Chun KW, Kim WK. Optimal concentration of thrombin to activate platelet for wound healing. J Korean Soc Plast Reconstr Surg 2009;36:19-23.

12. Kim JB, Chun KW, Han SK, Kim WK. Effect of human bone marrow stromal cell allograft on proliferation and collagen synthesis of diabetic fibroblasts in vitro. J Plast Reconstr Aesthet Surg 2010;63:1030-1035.

13. Lee CH, Han SK, Choi WI, Kim WK. Effect of human bone marrow stromal cells and dermal fibroblasts on collagen synthesis and epithelization. Ann Plast Surg 2007;59:713-719.

14. Han SK, Chun KW, Gye MS, Kim WK. The effect of human bone marrow stromal cells and dermal fibroblasts on angiogenesis. Plast Reconstr Surg 2006;117:829-835.

15. Han SK, Yoon TH, Lee DG, Lee MA, Kim WK. Potential of human bone marrow stromal cells to accelerate wound healing in vitro. Ann Plast Surg 2005;55:414-419.

Figure 1
Restoration of a facial defect by using an artificial dermis graft. Immediately (A) and 3 weeks after the graft (B).
jkma-54-594-g001-l.jpg
Figure 2
Restoration of a facial defect by using an autogenous dermis graft. Preoperative (A), 1 month (B), and 1 year (C) after the graft.
jkma-54-594-g002-l.jpg
Figure 3
Restoration of a facial defect by using a tissue-engineered dermis graft (fibroblast-hyaluronic acid complex). Immediately (A) and 1 year (B) after the graft.
jkma-54-594-g003-l.jpg
Figure 4
A man with chronic non-healing diabetic ulcer on dorsal forefoot of 12 week duration. Pre-operative view (A). Immediately after a graft of stromal vascular fraction (SVF) cells derived from adipose tissue (B). One (C), 2 (D), and 4 (E) weeks after the SVF cell graft. Five weeks after treatment (F), the wound was successfully closed.
jkma-54-594-g004-l.jpg
Figure 5
A man with chronic non-healing diabetic ulcer of 6 month duration. The wound healed after 7 weeks treated by blood bank platelet concentrates.
jkma-54-594-g005-l.jpg
Figure 6
An 70-year-old man's non-healing lower leg ulcer of 6 week duration. Preoperative view (A). One (B) and 4 (C) weeks after bone marrow stromal cell therapy. The wound was closed by a skin graft (D).
jkma-54-594-g006-l.jpg


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