Gastrointestinal Motility Modulating Drugs

Article information

J Korean Med Assoc. 2009;52(9):920-927
Publication date (electronic) : 2009 September 30
doi : https://doi.org/10.5124/jkma.2009.52.9.920
Department of Internal Medicine, Hanyang University College of Medicine, Korea. leeoy@hanyang.ac.kr

Abstract

Gastrointestinal motility modulating drugs include all compounds which have pharmacological activity of modulating (stimulating or inhibiting) gastrointestinal motility. They are mainly used for the treatment of functional gastrointestinal diseases. Gastrointestinal motility modulating drugs include 5HT receptor agonists, antagonists, and antidopaminergic agents. Many new gastrointestinal motility modulating drugs are currently under investigation. The aims of this article are to review the mechanism of action, efficacy and side effects of the gastrointestinal motility modulating drugs.

References

1. Karamanolis G, Tack J. Promotility medication-now and in the future. Dig Dis 2006. 24297–307.
2. Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther 2004. 19379–390.
3. Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol 2008. 8690–696.
4. Kindt S, Tack J. Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders. Neuogastroenterol Motility 2007. 1932–39.
5. Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum 2007. 50376–388.

Article information Continued

Table 1

Pharmacodynamic properties, gastrointestinal motor effects and side effects of gastrointestinal modulating drugs

Table 1

R: receptor, Sx: symptom, Pr: pressure,

AG: agonist, AT: antagonist

SSRI: selective serotonin reuptake inhibitor

GET (gastric emptying time)↑: accelerate , ↓:delay

CTT (colon transit time)↑: accelerate , ↓: delay

LES: low esophageal sphincter

TLESR↓: reduces transient low esophageal sphincter relaxation

GA (gastric accomodation) ↑: enhance, ↓: decrease