Several hot issues boiled our healthcare system in these years: off-label drug use, DUR, reuse of single-use devices (SUD), and conflicts in adopting new health technologies. Perhaps, most of conflicts among the stakeholders and policy makers of healthcare system can be explained by lack of communications and unsatisfactory efforts to understand each other. Evidence-based healthcare might be a solution, a common language to talk each other. Hence, it is worthwhile to assemble a strategic approach of evidence generation and synthesis of evidence. Furthermore, the introduction of conditional coverage decision in the national health insurance system is necessary to deal with uncertainty. To summarize, proper synthesis of evidence and a prudent use of it along with social values in decision making process is an answer to the conflicts. Now is the time to advance to a virtuous cycle of evidence-based healthcare.