Your browser does not support the NLM PubReader view.

Go to this page to see a list of supporting browsers.

Clinical Application of Nutrigenomics

Article information

J Korean Med Assoc. 2006;49(2):163-172
Publication date (electronic) : 2006 February 28
doi : https://doi.org/10.5124/jkma.2006.49.2.163
Mi Sun Kwak, Ph.D.1, Ki Baik Hahm, M.D.1, HJ Joung, Ph.D.2
1Department of Gastroenterology/Genome Research Center for Gastroenterology, Ajou University College of Medicine & Hospital, Korea. ms8686@hanmail.net, hahmkb@hotmail.com
2Postgraduate School of Public Health and Institute of Health and Environment, Seoul National University, Korea. hjjoung@snu.ac.kr

Abstract

Nutritional genomics (nutrigenomics) is the application of high-throughput functional genomics technologies to nutritional science lying in the interface between the nutritional environment and genetic process. It seeks to provide a molecular genetic understanding of how common dietary nutrition affects health by altering the expression or structure of an individual's genetic makeup. On the other hand, nutrigenetics is significantly different from nutrigenomics since nutrigenetics has been used for decades in certain rare monogenic diseases such as phenylketonuria, and has the potential to provide a basis for personalized dietary recommendation based on the individual's specific genetic background in order to prevent common multifactorial disorders decades before their clinical manifestation. The human genome maps and SNP databases, together with the rapid development of tools suitable for investigating genetic and epigenetic changes in small tissue biopsies provide the means to begin the test hypothesis about the mechanisms by which diet influences disease risk including cancer directly in human subjects, could be inevitable flatforms for clinical application to achieve targeted therapy in near future.

Keywords: Nutrigenomics; Nutrigenetics; SNP; Genome

References

1. Stover PJ. Nutritional genomics. Physiol Genomics 2004. 16161–165.
2. Davis CD, Milner J. Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutat Res 2004. 55151–64.
3. Kaput J, Rodriguez RL. Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics 2004. 16166–177.
4. Elliott R, Ong TJ. Nutritional genomics. BMJ 2002. 3241438–1442.
5. Muller M, Kersten S. Nutrigenomics: goals and strategies. Nat Rev Genet 2003. 4315–322.
6. Liu-Stratton Y, Roy S, Sen CK. DNA microarray technology in nutraceutical and food safety. Toxicol Lett 2004. 15029–42.
7. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat Res 2001. 47557–67.
8. Chatterjee M. Vitamin D and genomic stability. Mutat Res 2001. 47569–87.
9. Halliwell B. Vitamin C and genomic stability. Mutat Res 2001. 47529–35.
10. Claycombe KJ, Meydani SN. Vitamin E and genome stability. Mutat Res 2001. 47537–44.
11. Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991. 8811003–11006.
12. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rozen R, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996. 937–9.
13. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000. 72324–332.
14. Ordovas JM, Mooser V. Nutrigenomics and nutrigenetics. Curr Opin Lipidol 2004. 15101–108.
15. Mathers JC. The biological revolution-towards a mechanistic understanding of the impact of diet on cancer risk. Mutat Res 2004. 5543–49.
16. IHGSC. Initial sequencing and analysis of the human genome. Nature 2001. 409860–921.
17. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Holt RA, et al. The sequence of the human genome. Science 2001. 2911304–1351.
18. Roy S, Khanna S, Bentley K, Beffrey P, Sen CK. Functional genomics: high-density oligonucleotide arrays. Methods Enzymol 2002. 353487–497.
19. Roy S, Lado BH, Khanna S, Sen CK. Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Lett 2002. 53017–23.
20. Donaldson MS. Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 2004. 319.
21. Fairweather-Tait SJ. Human nutrition and food research: opportunities and challenges in the post-genomic era. Philos Trans R Soc Lond B Biol Sci 2003. 3581709–1727.
22. Kaput J. Diet-disease gene interactions. Nutrition 2004. 2026–31.
23. Kornman KS, Martha PM, Duff GW. Genetic variations and inflammation: a practical nutrigenomics opportunity. Nutrition 2004. 2044–49.

Article information Continued

Copyright © 2006 Korean Medical Association

Figure 1

Figure 1

What's different between nutrigenetics and nutrigenomic?

Figure 2

Figure 2

Nutrigenomics; How dose it influence disease pathogenesis?

Figure 3

Figure 3

Implication of nutrition in the generation and progression of various diseases

Figure 4

Figure 4

Kind and application of high throughput analysis for nutrigenomics

Figure 5

Figure 5

History of nutritional research associated with clinical disease

Figure 6

Figure 6

Perspective of nutrigenomics

Table 1

Definite or probable evidence showing the contribution of nutrition on disease

Table 1

Table 2

Examples of genomic polymorphisms on putative nutritional impact

Table 2