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J Korean Med Assoc > Volume 46(7); 2003 > Article
Kim: Recent Advances in the Diagnosis and Treatment for Rectal Cancer

Abstract

Optimal surgical treatment of rectal cancer is important to control local disease and preserve voiding and sexual function with a good quality of life. Anal sphincter preservation is a challenging issue in distal rectal cancer. Preoperative combined multimodality treatment might increase the rate of anal sphincter preservation. Postoperative adjuvant therapy with chemoradiation in stage II and III seems to increase survical rates and decrease local failure. To achieve the best oncologic and functional outcomes, the extent and type of surgery must be chosen based upon accurate preoperative staging of rectal cancer. Early cancer can be managed with minimal invasive surgery, however, neoadjuvant chemoradiation therapy on patients with locally advanced rectal cancer can improve resectability and oncologic outcomes. The rate of local failure is markedly decreased with the development of sharp pelvic dissection and the concept of total mesorectal excision. Total mesorectal excision is to remove rectal cancer and surrounding mesorectum completely without interruption of the rectal proper fascia. Optimized surgical technique and adjuvant chemoradiation can guarantee a promising oncologic outcomes ; however, difficulties of management of patients with local or systemic failure still remain.

References

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4. Kim NK, Kim MJ, SH Yun, Sohn SK, Min JS. Comparative study of transrectal ultrasonography, pelvic computerized tomography and magnetic resonance imaging in preoperative staging of rectal cancer. Dis Colon Rectum 1999;42:770-775.

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15. Kim NK, Ahn TW, Park JK, Lee KY, Lee WH, Min JS, et al. Assessment of sexual and voiding function after total mesorectal excision with pelvic autonomic nerve preservation in male with rectal cancer. Dis Colon Rectum 2002;45:1178-1185.

16. Havenga K, Enker WE, Norstein J, Moriya Y, Heald RJ, van de Velde CJ, et al. Improved survival and local control after total mesorectal excision or D3 lymphadenectomy in the treatment of primary rectal cancer : an international analysis of 1411 patients. Eur J Surg Oncol 1999;25:368-374.

23. Kim NK, Min JS, Park JK, Yun SH, Seong JS, Roh JK, et al. Intravenous 5 fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer. Jpn J Clin Oncol 2001;31:25-29.

25. Minsky BD. Adjvuant therapy of resectable rectal cancer. Cancer treatment reviews 2002;28:181-188.

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