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J Korean Med Assoc > Volume 62(2); 2019 > Article
Journal of the Korean Medical Association 2019;62(2):85-92.
Published online February 25, 2019.
DOI: https://doi.org/10.5124/jkma.2019.62.2.85   
Neurobiological understanding of suicide
Sangha Kim, Kyoung Uk Lee
Department of Psychiatry, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea. mindcure@catholic.ac.kr
Abstract
Suicide is a complex phenomenon resulting from interactions between individual vulnerabilities and socio-environmental factors. The current review primarily focuses on research into the serotonin system, hypothalamic-pituitary-adrenal axis, neurotrophic factors, lipid metabolism, and functional neuroimaging studies. It has been found that dysfunctions in the serotonin system, hypothalamic-pituitary-adrenal axis abnormalities, and low brain-derived neurotrophic factor and cholesterol levels may be linked to suicide. Additionally, recent neuroimaging studies have suggested that structural and functional abnormalities in brain areas related to cognitive and emotional regulation may be associated with suicide. More research incorporating advanced methodological approaches may shed further light on the neurobiological basis of suicide.
Key Words: Suicide, Neurobiology, Serotonin, Pituitary-adrenal system, Neuroimaging
 


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