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J Korean Med Assoc > Volume 52(11); 2009 > Article
Han: Novel Pharmacotherapies for Alzheimer's Disease

Abstract

Alzheimer disease (AD) is pathologically characterized by extracellular amyloid deposits composed of beta-amyloid (Aβ) peptide, neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau, and deficit of cholinergic neurons in the basal forebrain. It is the most common neurodegenerative disease in the elderly. With the aging of the population, the incidence and prevalence of AD will also increase rapidly. The subsequent growing socioeconomic burden seems to be inevitable until effective therapeutic strategies are developed. Currently available treatments approved by the US Food and Drug Administration, while ameliorating the symptoms, do not halt progression or cure the illness. AD is a multifactorial syndrome with several target proteins contributing to its etiology. In this review, various small molecules targeting pathological hall marks or their major constituents that have been reported in the literature will be discussed, with emphasis on compounds that are presently being investigated in clinical trials.

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Figure 1
The amyloid cascade hypothesis of Alzheimer's disease.
Aβ, amyloid beta protein; NFT, neurofibrillary tangle
jkma-52-1059-g001-l.jpg
Figure 2
Proteolytic processing of the b-amyloid precursor protein.
jkma-52-1059-g002-l.jpg
Figure 3
Chemical structure of resveratrol.
jkma-52-1059-g003-l.jpg


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