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J Korean Med Assoc > Volume 61(9); 2018 > Article
Journal of the Korean Medical Association 2018;61(9):552-556.
Published online September 18, 2018.
DOI: https://doi.org/10.5124/jkma.2018.61.9.552   
Treatment and prevention of acute exacerbation of chronic obstructive pulmonary disease
Seong Yong Lim, Hyun Jung Kim, Seung Won Ra, Ji Hyun Lee, Tae Hyung Kim
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. mdlimsy@skku.edu
2Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
3Department of Internal Medicine, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Korea.
4Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined as an acute aggravation of the patient's respiratory symptoms, particularly cough, sputum production, and dyspnea, which requires a change of medication. COPD exacerbation leads to an accelerated decline in lung function, poorer health status, and is the main cause of hospital admission and death in patients with COPD. A majority of COPD exacerbations are triggered by respiratory infection. The Management of acute exacerbation of COPD consists of systemic corticosteroids, antibiotics, and inhaled short-acting bronchodilators. Oxygen supplementation is an essential component of treatment to improve hypoxemia. Noninvasive or invasive ventilator support is necessary for COPD patients with severe exacerbation, particularly associated with hypercapnic respiratory failure. The Korean clinical practice guideline for COPD was revised in 2018 by the members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as participating members of the Health Insurance Review and Assessment Service. The purpose of this review is to provide an overview of the treatment and prevention strategies recommended in the 2018 Korean Academy of Tuberculosis and Respiratory Diseases for patient with acute exacerbation of COPD.
Key Words: Pulmonary disease, chronic obstructive, Acute exacerbation, Therapeutics, Prevention & control


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