Ethical Issues on Embryonic Stem Cell Research

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J Korean Med Assoc. 2005;48(10):1005-1012
Publication date (electronic) : 2005 October 31
doi : https://doi.org/10.5124/jkma.2005.48.10.1005
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Yongdong Severance Hospital, Korea. kyungseo@yumc.yonsei.ac.kr

Abstract

Harvesting stem cells is inevitably associated with destruction of early embryos. There have been continuing challenges to devaluate the moral status of early embryos. The distinction between preembryo and embryo was mainly based on the lack of individuation. The term preembryo had been introduced by a frog embryologist and then was literally spread around the world because of policy reasons. Thus the definition of preembryo is not yet complete and the term has not yet been used in most medical textbooks including textbooks of human embryology. Preembryo is a period during human development and therefore should be regarded as valuable as an early form of human life. Obtaining embryonic stem cells using SCNT (Somatic Cell Nuclear Transfer) is often called therapeutic cloning as opposed to reproductive cloning that produces human beings by SCNT. Therapeutic cloning used same SCNT to produce human embryos, and therefore it is essentially a process of human cloning. Human cloning is prohibited in most of the world due to ethical issues. Cloning primates including humans using SCNT has not been successful, however, recently there has been a remarkable progress with the help of improved technology of therapeutic cloning. Other countries also recognize the enormous potentials of cloned embryonic stem cells, but no country other than Korea and the UK has allowed therapeutic cloning for fear of the "slippery slope" towards human reproductive cloning. Ongoing researches of therapeutic cloning should be monitored carefully and a broad consensus is needed before allowing further therapeutic cloning. Eventually more ethical ways of obtaining embryonic stem cells should be developed.

References

4. Hwang WS, Ryu YJ, Park JH, Park ES, Lee EG, Koo JM, et al. Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 2004. 3031669.
7. HFEA grants the first therapeutic cloning licence for research. Human Fertilization and Embryology Authority of the UK 2004. Available from: URL: http://www.hfea.gov.uk/PressOffice/Archive/109223388.
8. HFEA grants embryonic stem cell research licence to study motor neuron disease. Human Fertilization and Embryology Authority of the UK 2005. Available from: URL: http://www.hfea.gov.uk/PressOffice/Archive/1107861560.
10. Moore KL, Persaud TVN. The Developing Human: Clinically Oriented Embryology 1998. 6th edth ed. Philadelphia: Saunders; 3.
11. Preembryo Research. Ethics in Obstetrics and Gynecology 2004. 92–100.
12. Braude P, Bolton V, Moore S. Human gene expression first occurs between the four-and eight-cell stage of preimplantation development. Nature 1988. 332459–461.
13. Edmonds DK, Lindsay KS, Miller JF, Williamson E, Wood PJ. Early embryonic mortality in women. Fertil Steril 1982. 38447–453.
14. Grobstein C. External human fertilization. Sci Am 1979. 24057–67.
15. Recommendations of the Warnock Committee. Lancet 1984. 07. 28. 2217–218.
16. The Ethics committee of the American Fertility Society. 1986. The biological characteristics of the preembryo. Fertil Steril 1986. 46suppl 1. 27s.
17. Cunningham FG, Jeveno KJ, Bloom SL, hauth JC, Gilstrap LC, Wenstrom KD. Wiliiams Obstetrics 21 edth ed. McGraw-Hill Medical Publishing Division; 93.
18. O'Rahilly R, Muller F. Human Embryology and Teratology 2000. 3rd edth ed. New York: Wiley-Liss; 87–88.
19. Mahowald MB. Maternal-fetal conflict: Positions and principles. Clin Obstet Gynecol 1992. 35729–737.
20. Therapeutic use of cell nuclear replacement: Therapeutic cloning. Medical research council Available from: URL: http://www.mrc.ac.uk/pdf_therapeutic_cloning.pdf.
21. Human cloning and human dignity. An ethical inquiry. The President's Council On Bioethics 2002. Washington DC: 87–116. Available from: URL: http://www.bioethics.gov/reports/cloningreport/.
22. Rideout WM, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001. 2931093–1097.
23. Simerly C, Dominko T, Navara C, Payne C, Capuano S, Gosman G, et al. Molecular correlates of primate nuclear transfer failures. Science 2003. 300297.
25. Pearson H. Biologists come close to cloning primates Oct 21 2004. Available from: URL: http://www.nature.com/news/2004/041018/pf/041018-12_pf.html.
26. Meng L, Ely JJ, Stouffer RL, Wolf DP. Rhesus monkeys produced by nuclear transfer. Biology of Reproduction 1997. 57454–459.
27. Somatic Cell Nuclear Transfer(Cloning) Efficiency Available from: URL: http://www.roslin.ac.uk/public/webtablesGR.pdf.
28. Hwang WS, Roh SI, Lee BC, Kang SK, Kwon DK, Kim S, et al. Patient-Specific embryonic stem cells derived from human SCNT blastocysts. Sciencexpress 2005. 05. 19. 1–8. Available from: URL: http://www.sciencexpress.org.
29. Position Statement: Human cloning: The need for a comprehensive ban. The Center for Bioethics and Human Dignity Available from: URL: http://www.cbhd.org/resources/clonong/position-statement.htm.
30. Daley GQ. Missed opportunities in embryonic stem-cell research. N Engl J Med 2004. 351627–628.
31. Human cloning and human dignity. An ethical inguiry. The President's Council on Bioethics 2002. Washington DC: 274–276. Available from: URL: http://www.bioethics.gov/reports/cloningreport/.
32. Landry DW, Zucker HA. Embryonic death and the creation of human embryonic stem cells. The Journal of Clinical Investigation 2004. 1141184–1186.

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