Cell Biological Characteristics of Adult Stem Cells

Yeong In Kim; Il-Hoan Oh

doi:10.5124/jkma.2005.48.10.993

J Korean Med Assoc > Volume 48(10); 2005 > Article

Kim and Oh: Cell Biological Characteristics of Adult Stem Cells

Continuing Education Column

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2005; 48(10): 993-1002.

Published online: October 31, 2005

DOI: http://dx.doi.org/10.5124/jkma.2005.48.10.993

Cell Biological Characteristics of Adult Stem Cells

Yeong In Kim, M.D., Il-Hoan Oh, M.D.

Catholic High-Performance Cell Therapy Center, The Catholic University of Korea, School of Medicine, Korea. nuyikim@catholic.ac.kr, iho@catholic.ac.kr

Abstract

Adult stem cells and embryonic stem cells are two counterparts of stem cells that can be used for the regeneration of organs and for cell therapy. While each stem cell has its own characteristics, recent findings on the plasticity of adult stem cells are expanding the horizons for cell therapy using these stem cells. In addition, adult stem cells are less prone to the transformation process or inappropriate ectopic differentiation. These characteristics of adult stem cells make them an attractive source of cell therapy and thus being actively exploited for their possible use in cell therapeutic treatment of many intractable diseases. However, many questions remain for the nature or mechanisms of plasticity in adult stem cells, and the task of inducing self-renewal for adult stem cell expansion and engineering has not been accomplished yet. Thus, for successful application of adult stem cells for cell therapy, further understanding on the nature of adult stem cells is necessary, which is critical for the development of high-performance cell therapy and to overcome current limitations in adult stem cell therapies.

Adult stem cell; Cell therapy; Self-renewal; Stem Cell Plasticity

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Cell Biological Characteristics of Adult Stem Cells

Abstract

References

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