Gastroenterologic Disorders in the Elderly

Article information

J Korean Med Assoc. 2005;48(2):132-139
Publication date (electronic) : 2005 February 28
doi : https://doi.org/10.5124/jkma.2005.48.2.132
Department of Medicinem, Sungkyunkwan University School of Medicine, Samsung Medical Center, Korea. sefamily@medimail.co.kr, Plrhee@smc.samsung.co.kr

Abstract

With the dramatic increase in the aging population, the practice and research on disorders in the elderly have become the topics of priority to both clinicians and researchers. Although most organ systems of the body undergo pathophysiological changes with aging, the gastroenterologic organs are known to be relatively unaffected by the aging process. This is probably due to the large functional reserve capacity of the gastroenterologic organs. Most gastroenterologic disorders occurring in younger individuals may also develop in the elderly, and for most gastroenterologists, age is hardly a dominant factor when establishing a management strategy. However, the presentation, treatment and prognosis of disease may be different between elderly and younger patients. One important thing to note is the high prevalence of certain disorders in the elderly. In this review, we focus on common gastroenterologic disorders in the Korean elderly, for example, gastro-esophageal reflux disease (GERD), peptic ulcer, stomach cancer, colon adenoma and cancer, inflammatory bowel disease, liver and gall bladder and pancreas disorders, acute peritonitis, and some other disorders. The incidences of these disorders tend to increase with age and their pathophysiological and clinical characteristics may be different in the elderly from in young or adult people. For the better care of gastroenterologic disorders in the elderly we need to understand the pathophysiologic changes of the gastroenterologic organs associated with aging and the clinical differences of common gastroenterologic disorders in the elderly.

References

1. Holt PR. Gastrointestinal system: changes in morphology and cell proliferation. Aging (Milano) 1991. 3392–394.
2. Russell RM. Changes in gastrointestinal function attributed to aging. Am J Clin Nutr 1992. 556 Suppl. 1203S–1207S.
3. Hong WS. Clinically important gastroenterologic disorders in Korean elderly. Korean J Gastroenterol 2003. 42257–266.
4. Ren J, Shaker R, Kusano M, Podvrsan B, Metwally N, Sui Z, et al. Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol 1995. 268G772–G779.
5. Xie P, Ren J, Bardan E, Mittal RK, Sui Z, Shaker R. Frequency of gastroesophageal reflux events induced by pharyngeal water stimulation in young and elderly subjects. Am J Physiol 1997. 272G233–G237.
6. Grande L, Lacima G, Ros E, Pera M, Ascaso C, Pera C, et al. Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am J Gastroenterol 1999. 941795–1801.
7. Amano K, Adachi K, Katsube T, Watanabe M, Kinoshita Y. Role of hiatus hernia and gastric mucosal atrophy in the development of reflux esophagitis in the elderly. J Gastroenterol Hepatol 2001. 16132–136.
8. Tack J, Vantrappen G. The aging oesophagus. Gut 1997. 41422–424.
9. Kennedy T, Jones R. The prevalence of gastro-oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 2000. 141589–1594.
10. Pilotto A. Aging and upper gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004. 18Suppl. 73–81.
11. Raiha I, Hietanen E, Sourander L. Symptoms of gastro-oesophageal reflux disease in elderly people. Age Ageing 1991. 20365–370.
12. Collen MJ, Abdulian JD, Chen YK. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol 1995. 901053–1057.
13. Maekawa T, Kinoshita Y, Okada A, Fukui H, Waki S, Matsushima Y, et al. Relationship between severity and symptoms of reflux oesophagitis in elderly patients in Japan. J Gastroenterol Hepatol 1998. 13927–930.
14. James OF, Parry-Billings KS. Comparison of omeprazole and histamine H2-receptor antagonists in the treatment of elderly and young patients with reflux oesophagitis. Age Ageing 1994. 23121–126.
15. Pilotto A, Leandro G, Franceschi M. Short-and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole. Aliment Pharmacol Ther 2003. 171399–1406.
16. Pilotto A, Franceschi M, Leandro G, Novello R, Di Mario F, Valerio G. Long-term clinical outcome of elderly patients with reflux esophagitis: a six-month to three-year follow-up study. Am J Ther 2002. 9295–300.
17. Steinheber FU. Ageing and the stomach. Clin Gastroenterol 1985. 14657–688.
18. Moore JG, Tweedy C, Christian PE, Datz FL. Effect of age on gastric emptying of liquid-solid meals in man. Dig Dis Sci 1983. 28340–344.
19. Higham J, Kang JY, Majeed A. Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects. Gut 2002. 50460–464.
20. Pilotto A, Malfertheiner P. Review article: an approach to Helicobacter pylori infection in the elderly. Aliment Pharmacol Ther 2002. 16683–691.
21. Murakami M, Saita H, Takahashi Y, Kusaka S, Asagoe K, Matsumoto M, et al. Therapeutic effects of lansoprazole on peptic ulcers in elderly patients. J Clin Gastroenterol 1995. 20Suppl 2. S79–S82.
22. Pilotto A, Franceschi M, Leandro G, Bozzola L, Fortunato A, Meli S, et al. Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter pylori infection in elderly patients. J Gastroenterol Hepatol 1999. 14468–475.
23. Ammon S, Treiber G, Kees F, Klotz U. Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. Aliment Pharmacol Ther 2000. 14759–766.
24. Pilotto A. Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. Drugs Aging 2001. 18487–494.
25. Pilotto A, Franceschi M, Leandro G, Di Mario F. NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging 2003. 20701–710.
26. Pilotto A, Franceschi M, Leandro G, Paris F, Niro V, D'Ambrosio LP, et al. The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res 2003. 15494–499.
27. Leandro G, Pilotto A, Franceschi M, Bertin T, Lichino E, Di Mario F. Prevention of acute NSAID-related gastroduodenal damage: a meta-analysis of controlled clinical trials. Dig Dis Sci 2001. 461924–1936.
28. Brock J, Sauaia A, Ahnen D, Marine W, Schluter W, Scinto JD, et al. Process of care and outcomes for elderly patients hospitalized with peptic ulcer disease: results from a quality improvement project. JAMA 2001. 2861985–1993.
29. Jones AC, Coulson L, Muir K, Tolley K, Lophatananon A, Pringle M, et al. A nurse-delivered advice intervention can reduce chronic non-steroidal anti-inflammatory drug use in general practice: a randomized controlled trial. Rheumatology (Oxford) 2002. 4114–21.
30. Mamdani M, Rochon PA, Juurlink DN, Kopp A, Anderson GM, Austin PC, et al. Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ 2002. 325624.
31. White WB, Whelton A. Cardiovascular events and COX-2 inhibitors. JAMA 2001. 2862811–2812.
32. Yodfat Y. Is there a future for COX-2 inhibitors? Harefuah 2004. 143820–824.
33. Arai T, Esaki Y, Inoshita N, Sawabe M, Kasahara I, Honma N, et al. Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer 2004. 7154–159.
34. Song BC, Choi JW, Choi WB, Youn KH, Joo YH, Joo KR, et al. Clinicopathological features of gastric carcinoma in the Korean elderly. J Korean Geriatr Soc 1997. 135–42.
35. Kitagawa M, Utsuyama M, Kurata M, Yamamoto K, Yuasa Y, Arai T, et al. Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo. Cancer Immunol Immunother 2004.
36. Inoshita N, Yanagisawa A, Arai T, Kitagawa T, Hirokawa K, Kato Y. Pathological characteristics of gastric carcinomas in the very old. Jpn J Cancer Res 1998. 891087–1092.
37. Katai H, Sasako M, Sano T, Fukagawa T. Gastric cancer surgery in the elderly without operative mortality. Surg Oncol 2004. 13235–238.
38. Madsen JL, Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing 2004. 33154–159.
39. Rumiantsev VG, Bondarenko EIu. Chronic constipations in elderly people. Eksp Klin Gastroenterol 2004. 10948–54.
40. Wald A. Constipation and fecal incontinence in the elderly. Semin Gastrointest Dis 1994. 5179–188.
41. Camilleri M, Lee JS, Viramontes B, Bharucha AE, Tangalos EG. Insights into the pathophysiology and mechanisms of constipation, irritable bowel syndrome, and diverticulosis in older people. J Am Geriatr Soc 2000. 481142–1150.
42. Youn SJ, Kim NY, Kim YT, Jung HC, Lee HS, Yoon YB, et al. Colorectal polyp in Korea. Korean J Gastroenterol 1991. 23450–458.
43. Lee DH, Cho MK, Yu CS, Kim HC, Jung HY, Yang SK, et al. Clinicopathologic study of colorectal polyps. Korean J Gastroenterol 2000. 36302–316.
44. Provenzale D, Garrett JW, Condon SE, Sandler RS. Risk for colon adenomas in patients with rectosigmoid hyperplastic polyps. Ann Intern Med 1990. 113760–763.
45. Au HJ, Mulder KE, Fields AL. Systematic review of management of colorectal cancer in elderly patients. Clin Colorectal Cancer 2003. 3165–171.
46. Berner Y, Vigder C, Stern M, Feldman J. Inflammatory Bowel diseases in the elderly. Harefuah 2003. 142188–192.
47. Piront P, Louis E, Latour P, Plomteux O, Belaiche J. Epidemiology of inflammatory bowel diseases in the elderly in the province of Liege. Gastroenterol Clin Biol 2002. 26157–161.
48. Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OF. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 1989. 9297.
49. Woodhouse KW, James OF. Hepatic drug metabolism and ageing. Br Med Bull 1990. 4622–35.
50. Kim MH, Lim BC, Myung SJ, Lee SK, Ohrr HC, Roe IH, et al. Epidemiological study on Korean gallstone disease: a nationwide cooperative study. Dig Dis Sci 1999. 441674–1683.
51. Lee SK, Seo DW, Myung SJ, Park ET, Lim BC, Yoo KS, et al. Percutaneous transhepatic cholangioscopic treatment for hepatolithiasis: an evaluation of long-term results and risk factors for recurrence. Gastrointest Endosc 2001. 53318–323.
52. Kim CD. Current status of acute pancreatitis in Korea. Korean J Gastroenterol 2003. 421–11.
53. Kim JP, Kim SJ, Lee JH, Kim SW, Choi MG, Yu HJ. Surgery in the aged in Korea. Arch Surg 1998. 13318–23.
54. Bender JS. Approach to the acute abdomen. Med Clin North Am 1989. 731413–1422.
55. Hendrickson M, Naparst TR. Abdominal surgical emergencies in the elderly. Emerg Med Clin North Am 2003. 21937–969.

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