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J Korean Med Assoc > Volume 63(1); 2020 > Article
Bae, Lee, and Park: Drug-induced nephrotoxicity

Abstract

Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and tends to increase among certain patients and/or with complex clinical conditions. Unfortunately, apart from conservative management, including drug withdrawal, no effective treatment is known for this condition. Therefore, in order to reduce the frequency of drug-induced nephrotoxicity, early recognition of renal toxicity and appropriate prevention strategies, such as understanding the exact mechanisms of renal injury, patient and drug-related risk factors, and preemptive measures are needed. In this review, we will present the mechanisms of drug-induced nephrotoxicity and general preventive strategies for clinical physicians.

Notes

No potential conflict of interest relevant to this article was reported.

References

1. Mehta RL, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Chertow GM. Program to Improve Care in Acute Renal Disease. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 2004;66:1613-1621.
crossref pmid
2. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C. Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005;294:813-818.
crossref pmid
3. Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honoré PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 2015;41:1411-1423.
crossref pmid pdf
4. Markowitz GS, Perazella MA. Drug-induced renal failure: a focus on tubulointerstitial disease. Clin Chim Acta 2005;351:31-47.
crossref pmid
5. Perazella MA. Renal vulnerability to drug toxicity. Clin J Am Soc Nephrol 2009;4:1275-1283.
crossref pmid
6. Perazella MA. Drug-induced nephropathy: an update. Expert Opin Drug Saf 2005;4:689-706.
crossref pmid
7. Perazella MA. Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. Am J Med Sci 2003;325:349-362.
crossref pmid
8. Hoste EA, Kellum JA. Acute kidney injury: epidemiology and diagnostic criteria. Curr Opin Crit Care 2006;12:531-537.
crossref pmid
9. Kohli HS, Bhaskaran MC, Muthukumar T, Thennarasu K, Sud K, Jha V, Gupta KL, Sakhuja V. Treatment-related acute renal failure in the elderly: a hospital-based prospective study. Nephrol Dial Transplant 2000;15:212-217.
crossref pmid
10. Schetz M, Dasta J, Goldstein S, Golper T. Drug-induced acute kidney injury. Curr Opin Crit Care 2005;11:555-565.
crossref pmid
11. Zager RA. Pathogenetic mechanisms in nephrotoxic acute renal failure. Semin Nephrol 1997;17:3-14.
pmid
12. Choudhury D, Ahmed Z. Drug-associated renal dysfunction and injury. Nat Clin Pract Nephrol 2006;2:80-91.
crossref pmid pdf
13. Whelton A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med 1999;106:13S-24S.
crossref pmid
14. Ahn GY, Bae SC. Strategies for the safe use of non-steroidal anti-inflammatory drugs. J Korean Med Assoc 2018;61:367-375.
crossref pdf
15. Kobori H, Mori H, Masaki T, Nishiyama A. Angiotensin II blockade and renal protection. Curr Pharm Des 2013;19:3033-3042.
crossref pmid pmc
16. Olyaei AJ, de Mattos AM, Bennett WM. Immunosuppressant-induced nephropathy: pathophysiology, incidence and management. Drug Saf 1999;21:471-488.
pmid
17. Markowitz GS, Fine PL, Stack JI, Kunis CL, Radhakrishnan J, Palecki W, Park J, Nasr SH, Hoh S, Siegel DS, D'Agati VD. Toxic acute tubular necrosis following treatment with zoledronate (Zometa). Kidney Int 2003;64:281-289.
crossref pmid
18. Ko GJ. Contrast-induced nephropathy. Korean J Med 2015;88:375-381.
crossref pdf
19. Markowitz GS, Appel GB, Fine PL, Fenves AZ, Loon NR, Jagannath S, Kuhn JA, Dratch AD, D'Agati VD. Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate. J Am Soc Nephrol 2001;12:1164-1172.
crossref pmid
20. Praga M, González E. Acute interstitial nephritis. Kidney Int 2010;77:956-961.
crossref pmid
21. Cho MK, Kang DY, Kang HR. Adverse drug reactions. J Korean Med Assoc 2019;62:472-479.
crossref pdf
22. Rossert J. Drug-induced acute interstitial nephritis. Kidney Int 2001;60:804-817.
crossref pmid
23. Baek JY, Kim EI, Kim YO, Choi YS, Suh JP, Kim JS, Yoon SA, Bang BK. A case of acyclovir induced acute interstitial nephritis. Korean J Nephrol 2000;19:1159-1162.

24. Han EJ, Kim SM, Lee HS, Jeon SC, Jung YJ, Yim H, Cho SW, Kim H, Shin GT. Entecavir-induced tubulointerstitial nephritis. Korean J Nephrol 2010;29:504-508.

25. Simpson IJ, Marshall MR, Pilmore H, Manley P, Williams L, Thein H, Voss D. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology (Carlton) 2006;11:381-385.
crossref pmid
26. Perazella MA. Crystal-induced acute renal failure. Am J Med 1999;106:459-465.
crossref pmid
27. Huerta-Alardín AL, Varon J, Marik PE. Bench-to-bedside review: Rhabdomyolysis: an overview for clinicians. Crit Care 2005;9:158-169.
pmid
28. Coco TJ, Klasner AE. Drug-induced rhabdomyolysis. Curr Opin Pediatr 2004;16:206-210.
crossref pmid
29. Pisoni R, Ruggenenti P, Remuzzi G. Drug-induced thrombotic microangiopathy: incidence, prevention and management. Drug Saf 2001;24:491-501.
pmid
30. Dickenmann M, Oettl T, Mihatsch MJ. Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes. Am J Kidney Dis 2008;51:491-503.
crossref pmid
31. Guo X, Nzerue C. How to prevent, recognize, and treat drug-induced nephrotoxicity. Cleve Clin J Med 2002;69:289-296.
crossref pmid
32. Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med 2004;351:159-169.
crossref pmid
33. Leblanc M, Kellum JA, Gibney RT, Lieberthal W, Tumlin J, Mehta R. Risk factors for acute renal failure: inherent and modifiable risks. Curr Opin Crit Care 2005;11:533-536.
crossref pmid
34. Kim SY. Preventing acute kidney injury induced by contrast medium. Korean J Nephrol 2007;26:657-659.

35. Barrett BJ, Parfrey PS. Clinical practice. Preventing nephropathy induced by contrast medium. N Engl J Med 2006;354:379-386.
crossref pmid
36. Pazhayattil GS, Shirali AC. Drug-induced impairment of renal function. Int J Nephrol Renovasc Dis 2014;7:457-468.
pmid pmc
37. Bauer L. Creatinine clearance versus glomerular filtration rate for the use of renal drug dosing in patients with kidney dysfunction. Pharmacotherapy 2005;25:1286-1287.
crossref pmid
38. Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS. Chronic Kidney Disease Epidemiology Collaboration. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis 2009;54:33-42.
crossref pmid pmc
39. Kaufman J, Dhakal M, Patel B, Hamburger R. Community-acquired acute renal failure. Am J Kidney Dis 1991;17:191-198.
crossref pmid
40. Gurwitz JH, Field TS, Harrold LR, Rothschild J, Debellis K, Seger AC, Cadoret C, Fish LS, Garber L, Kelleher M, Bates DW. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 2003;289:1107-1116.
crossref pmid
41. Naughton CA. Drug-induced nephrotoxicity. Am Fam Physician 2008;78:743-750.
pmid
Table 1

Drugs associated with nephrotoxicity according to pathogenic mechanisms

jkma-63-30-i001.jpg

Information from references [4,10,11,12].

NSAID, nonsteroidal anti-inflammatory drug; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blockers; COX-2, cyclooxygenase-2; IVIG, intravenous immune globulin.

Table 2

General preventive strategies to prevent drug-induced nephrotoxicity

jkma-63-30-i002.jpg

Information from references [10,12,36].

MDRD, Modification of Diet in Renal Disease; CG, Cockcroft and Gault; eGFR, estimated glomerular filtration rate.

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