Neural Stem Cells for Neurological Disorders

Jae-Kyu Roh; Manho Kim; Kon Chu

doi:10.5124/jkma.2004.47.10.940

J Korean Med Assoc > Volume 47(10); 2004 > Article

Roh, Kim, and Chu: Neural Stem Cells for Neurological Disorders

Special Issue

Recent Advances in Stem Cell Research

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2004; 47(10): 940-947.

Published online: October 30, 2004

DOI: http://dx.doi.org/10.5124/jkma.2004.47.10.940

Neural Stem Cells for Neurological Disorders

Jae-Kyu Roh, M.D., Manho Kim, M.D., Kon Chu, M.D.

Stroke & Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University College of Medicine & Hospital, Korea. rohjk@snu.ac.kr, kimmanho@snu.ac.kr, stemgen1@snu.ac.kr

Abstract

Recent progress shows that neurons suitable for transplantation can be generated from neural stem cells (NSCs) in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. In this article, we discuss how the subventricular zone of the forebrain is the most active neurogenetic area and the richest source of NSCs. This review also focuses on the nature and functional properties of NSCs of the adult mammalian brain, and we propose our views on the strategy from bench to the clinic with particular concerns and considerations.

Neural stem cell; Transplantation; Neurological disorder

References

1. Galli R, Gritti A, Bonfanti L, Vescovi AL. Neural stem cells: an overview. Circ Res 2003;92:598-608.

2. Ryder EF, Snyder EY. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J Neurobiol 1990;21:356-375.

3. Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartweig EA, Cepko CL. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 1992;68:33-51.

4. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-1710.

5. Imitola J, Park KI, Teng YD, Nisim S, lachyankar M, Snyder EY, et al. Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci 2004;359:823-837.

6. Snyder EY, Daley GQ, Goodell M. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res 2004;76:157-168.

7. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 2004;10:Supp 1. S42-S50.

8. Bjorklund A, Lindvall O. Cell replacement therapies for central nervous system disorders. Nat Neurosci 2000;3:537-544.

9. McKay R. Stem cells in the central nervous system. Science 1997;276:66-71.

10. Alvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci 2001;2:287-293.

11. Steindler DA, Kadrie T, Fillmore H, Thomas LB. The subependymal zone: brain marrow. Prog Brain Res 1996;108:349-363.

12. Scheffler B, Horn M, Blumcke I, Laywell ED, Coomes D, Steindler DA, et al. Marrow-mindedness: a perspective on neuropoiesis. Trends Neurosci 1999;22:348-357.

13. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature 2000;405:951-955.

14. Temple S, Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Curr Opin Neurobiol 1999;9:135-141.

15. Arvidsson A, Collin T, Kirik D, Kokaia Z, Linvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002;8:963-970.

16. Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Greenberg DA, et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci U S A 2001;98:4710-4715.

17. Kokaia Z, Lindvall O. Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol 2003;13:127-132.

18. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 2002;52:802-813.

19. Nakatomi H, Kuriu T, Okabe S, Yamamoto S, hatano O, Nakafuku M, et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002;110:429-441.

20. Jung KH, Chu K, Kim M, Jeong SW, Song YM, Roh JK, et al. Continuous cytosine-b-D-arabionofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Eur J Neurosci 2004;19:3219-3226.

21. Sanai N, Tramontin AD, Quinones-Hinojosa A, Barbaro NM, Gupta N, Alvarez-Buylla A, et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 2004;427:740-744.

22. Rothstein JD, Snyder EY. Reality and immortality-neural stem cells for therapies. Nat Biotechnol 2004;22:283-285.

23. Chu K, Kim M, Jung KH, Park KI, Lee ST, Roh JK, et al. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res 2004;1016:145-153.

24. Jeong SW, Chu K, Jung KH, Kim SU, Kim M, Roh JK. Intravenous human neural stem cell transplantation promotes functional recovery with experimental intracranial hemorrhage in the adult rats. Stroke 2003;34:2258-2263.

25. Chu K, Kim M, Jung KH, Jeon D, Lee ST, Roh JK, et al. Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res 2004;1023:213-221.

26. Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Bynum L, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000;55:565-569.

27. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Gage FH, et al. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 2004;430:350-356.

28. Lang AE, Obeso JE. Challenges in Parkinsons disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol 2004;3:309-316.

29. Chu K, Kim M, Jeong SW, Kim SU, Yoon BW. Human neural stem cells can migrate, differentiate and proliferate after intravenous transplantation in the adult rats with transient forebrain ischemia. Neurosci Lett 2003;343:129-133.

30. Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Roh JK, et al. Celecoxib Induces Functional Recovery after Intracerebral Hemorrhage with Reduction of Brain Edema and Perihematomal Cell Death. J Cereb Blood Flow Metab 2004;24:926-933.

31. Jung KH, Chu K, Jeong SW, Han SY, Lee ST, Roh JK, et al. HMG-CoA reductase inhibitor, atorvastatin, ameliorates sensorimotor dysfunctions in experimental intracerebral hemorrhage. Stroke 2004;35:1744-1749.

32. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Martino G, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 2003;422:688-694.

33. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Snyder EY, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000;97:12846-12851.