Hepatic Stem Cell Transplantation in Liver Failure
Article information
J Korean Med Assoc. 2004;47(10):933-939
Publication date (electronic) : 2004 October 30
doi :
https://doi.org/10.5124/jkma.2004.47.10.933
Abstract
Whole or partial liver transplantation has become one of the main treatment strategies for hepatic failure. The availability of a donor liver is the single most limiting factor in liver transplantation. In cell therapy, liver cells have been used clinically to bridge patients to whole organ transplantation and/or as an alternative to whole organ transplants. The crucial property that defines a stem cell is its ability to give rise to a large family of descendants, and at least some hepatocytes do exhibit this pleuripotency. Thus hepatocyte-like cells derived from the bone marrow, embryonal stem cells, or placental sources can also be used. Stem cells of many types have been prodded and cajoled by combinations of growth factors, matrix and culture modifications to identify conditions that favor differentiation or transdifferentiation of stem/progenitor cells into hepatocytes. Additional studies are needed to determine whether hepatocyte-like cells derived from the bone marrow or other sources express the full complement of hepatic functions. If a sufficient number of differentiated hepatocytes can be produced from these stem cells, they could be useful in clinical transplantation programs.
Keywords: Hepatocyte transplantation; Hepatic stem cell; Liver failure
References
1. Wong KK, De Pinho RA. Walking the telomere plank into cancer. J Natl Cancer Inst 2003. 951184–1186.
2. Overturf K, al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997. 1511273–1280.
3. Alison MR. Liver regeneration with reference to stem cells. Semin Cell Dev Biol 2002. 13385–387.
4. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T. Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 1997. 25329–334.
5. Hooth MJ, Coleman WB, Presnell SC, Borchert KM, Grisham JW, Smith GJ. Spontaneous neoplastic transformation of WBF344 rat liver epithelial cells. Am J Pathol 1998. 1531913–1921.
6. Ott M, Rajvanshi P, Sokhi R, Alpini G, Aragona E, Dabeva M, et al. Differentiation-specific regulation of transgene expression in a diploid epithelial cell line derived from the normal F344 rat liver. J Pathol 1999. 187365–373.
7. Dabeva MD, Hwang SG, Vasa SR, Hurston E, Novikoff PM, Hixson DC, et al. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci USA 1997. 947356–7361.
8. Wang X, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol 2001. 158571–579.
9. Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci 2003. 10011881–11888.
10. Jones EA, Tosh D, Wilson DI, Lindsay S, Forrester LM. Hepatic differentiation of murine embryonic stem cells. Exp Cell Res 2002. 27215–22.
11. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, et al. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology 2003. 37983–993.
12. Chinzei R, Tanaka Y, Shimizu-Saito K, Hara Y, Kakinuma S, Watanabe M, et al. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 2002. 3622–29.
13. Hamilton WJ, Boyd JD, eds. Human embryology 1964. 3rd edth ed. Cambridge: Heffer; 240–244.
14. Arias DM, Boyer JL, eds. The liver biology, biology and pathobiology 1994. 3rd edth ed. New York: Lippincott Williams & Wilkins; 1501–1508.
15. Dabeva MD, Petkov PM, Sandhu J, Oren R, Laconi E, Hurston E, et al. Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation into adult rat liver. Am J Pathol 2000. 1562017–2031.
16. Malhi H, Irani AN, Gagandeep S, Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci 2002. 1152679–2688.
17. Sigal S, Gupta S, Gebhard DF Jr, Holst P, Neufeld D, Reid LM. Evidence for a terminal differentiation process in the liver. Differentiation 1999. 5935–42.
18. Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells. Am J Pathol 2001. 1591323–1334.
19. Habibullah CM. Hepatocyte transplantation: need for liver cell bank. Trop Gastroenterol 1992. 13129–131.
20. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri RK, et al. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 2003. 124432–444.
21. Zaizman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, et al. Reversal of hyperglycemia in mice using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 2003. 1007253–7258.
22. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999. 2841168–1170.
23. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000. 31235–240.
24. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002. 346738–746.
25. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osbome L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000. 61229–1234.
26. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little Evidence for developmental plasticity of adult hematopoietic Stem Cells. Science 2002. 2972256–2259.
27. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003. 422897–901.
28. Newsome PN, Johannessen I, Boyle S, Dalakas E, McAulay KA, Samuel K, et al. Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 2003. 1241891–1900.
29. Austin TW, Lagasse E. Hepatic regeneration from hematopoietic stem cells. Mech Dev 2003. 120131–135.
30. Kim DK, Fujiki Y, Fukushima T, Ema H, Shibuya A, Nakauchi H. Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells. Stem Cells 1999. 17286–294.
31. Tang XP, Yang X, Tan H, Ding YL, Zhang M, Wang WL. Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis. World J Gastroenterol 2003. 91999–2003.
32. Strom SC, Fisher RA, Rubinstein WS, Barranger JA, Towbin RB, Reyes J, et al. Transplantation of human hepatocytes. Transplant Proc 1997. 292103–2106.
33. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Posner MP, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997. 63559–569.
34. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Strom SC, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. New Engl J Med 1998. 3381422–1426.
35. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Durham J, et al. Hepatocyte transplantation in acute liver failure. Liver Transpl 2000. 632–40.
36. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994. 58951–952.
Article information Continued
Copyright © 2004 Korean Medical Association