Renal Disease in the Elderly

Article information

J Korean Med Assoc. 2004;47(3):258-267
Publication date (electronic) : 2004 March 31
doi : https://doi.org/10.5124/jkma.2004.47.3.258
Division of Nephrology & Kidney Center, Inha University College of Medicine & Hospital, Korea. nhkimj@inha.ac.kr

Abstract

Aging is a normal degenerative biologic process that affects many organs, of which the kidney is one of the most prominently affected. Physicians who treat elderly patients must be aware of the decline in renal function that accompanies the aging process. The findings of urinary abnormalities or a decreased glomerular filtration rate (GFR) in elderly patients should alert clinicians to fully evaluate the renal function. GFR decreases steadily, starting in the middle age. Evaluation of elderly patients should include careful consideration of possible fluid and electrolyte disturbances. Acute renal failure is most frequent among the aged, mainly due to the comorbidities and the intervention they require. Diabetes and renovascular diseases including hypertension now account for most of the cases ofchronic kidney disease. The elderly are the fastest growing population of patients requiring renal replacement therapy in this aging society. This represents one of the great public health issues.

References

1. Lindeman RD. Overview: renal physiology and pathophysiology of aging. Am J Kidney Dis 1990. 16(4)275–282.
2. Brown WW. Introduction: Aging and the kidney. Adv Ren Replace Ther 2000. 7(1)1–3.
3. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976. 16(1)31–34.
4. Mimran A, Ribbstein J, Jover B. Aging and sodium homeostasis. Kidney Int Suppl 1992. 37s107–s113.
5. Rowe JW, Shock NW, DeFronzo RA. The influence of age on the renal response to water deprivation in man. Nephron 1976. 17(4)270–278.
6. Grero PS, Hodkinson HM. Hypercalcaemia in elderly hospital in-patients:value of discriminant analysis in differential diagnosis. Age Ageing 1977. 6(1)14–20.
7. Cameron JS. Nephrotic syndrome in the elderly. Semin-Nephrol 1996. 16(4)319–329.
8. Ponticelli C, Passerini P, Como G, Melis P, Vigano E, Pozzi C. Primary nephrotic syndrome in the elderly. Contrib Nephrol 1993. 10533–37.
9. Korbert SM, Schwartz MM, Lewis EJ. Minimal-change glomerulopathy of adulthood. Am J Nephrol 1988. 8(4)291–297.
10. Haas M, Spargo BH, Wit EJ, Meehan SM. Etiologies and outcome of acute renal insufficiency in older adults:a renal biopsy study of 259 cases. Am J Kidney Dis 2000. 35(3)433–447.
11. Bakris GL, Kern SR. Renal dysfunction resulting from NSAIDs. Am Fam Physician 1989. 40(4)199–204.
12. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for CKD. V. : Definition and classification of stages of chronic kidney disease 2002. New York, NY: National Kidney Foundation;
13. Bailey JL, England BK, Long RC Jr, Mitch WE. In : Brenner BM, ed. Pathophysiology of uremia. the Kidney (vol 2) 2000. 6th edth ed. Philadelphia: W.B. Saunders; 2059–2078.
14. Chan L, Schrier RW. In : Schrier RW, ed. Chronic renal failure: Manifestations and pathogenesis. Renal and Electrolyte Disorders 1997. 6th edth ed. Philadelphia: Lippincott-Raven Publishers; 507–547.
15. Wedr AB. The renally compromised older hypertensive:therapeutic considerations. Geriatrics 1991. 46(2)36–46.
17. Churchill DN, Blake PG, Jindal KK, Teffelmire EB. Clinical practice guidelines for initiation of dialysis. J Am Soc Nephrol 1999. 10s289–s291.

Article information Continued

Table 1

Table 1

Table 2

Table 2

Table 3

Table 3

Shaded area identifies patients who have chronic kidney disease ; unshaded area designates individuals who are at increased risk for developing chronic kidney disease. Chronic kidney disease is defined as either kidney damage or GFR < 60 mL/min/1.73 m2

Abbreviations : GFR , glomerular filtration rate ; CKD, chronic kidney disease ; CVD, cardiovascular disease