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Clinical Application of Capsule Endoscope

Article information

J Korean Med Assoc. 2003;46(8):743-752
Publication date (electronic) : 2003 August 31
doi : https://doi.org/10.5124/jkma.2003.46.8.743
Hoon Jai Chun, M.D.
Department of Gastroenterology, Korea University College of Medicine, Anam Hospital, Korea. kumcge@chollian.net

Abstract

Wireless capsule endoscopy is currently the outstanding technical innovation in diagnostic gastrointestinal endoscopy. Especially for small bowel diseases this new technique offers several potential advantages over traditional diagnostic tools. The Given Diagnostic Imaging System (Given Imaging Ltd, Norcross, GA) consists of 3 components : the M2A capsule, an external receiving antenna with an attached portable hard drive, and a personal computer workstation for review and interpretation of images. The M2A capsule is a single-use device measuring 11×26 mm and weighing 3.7 g. It is made of a biocompatible plastic and contains a complimentary metal oxide silicon chip camera, lens, light source, battery, and radio telemetry transmitter. Images are transmitted at 2 per second to an antenna array worn on the abdomen and stored on a Walkman-sized data recorder. The Given system was approved by the Food and Drug Administration in August 2001. The method has chiefly been used in patients with obscure gastrointestinal bleeding, and in some cases has allowed additional diagnoses to be made in comparison with push enteroscopy, with a positive influence on patient management. Contraindications to performance of capsule endoscopy include known or suspected GI obstruction, strictures or fistula, and presence of a cardiac pacemaker, defibrillator, or other implanted electromedical device. The M2A capsule is probably just the first in a long line of wireless endoscopic devices. There are already prototypes of self-propelled devices. Soon to come will real-time imaging, devices to image the proximal GI tract and colon, and devices that can take biopsies or provide therapy.

Keywords: Capsule endoscope; Small bowel disease

References

1. Fleischer DE. Capsule endoscopy : the voyage is fantastic-will it change what we do? Gastrointest Endosc 2002. 56452–456.
2. Fritscher-Ravens A, Swain CP. The wireless capsule : new light in the darkness. Dig Dis 2002. 20127–133.
3. Iddan G, Meron G, Glukhovsky A, Swain P. Wireless capsule endscopy. Nature 2000. 405417.
4. Appleyard M, Mosse C, Mills T, Swain P. Electrostimulation to move endoscopes in the small bowel. Endoscopy 2000. 32E59.
5. Appleyard MN, Gong F, Mills T, Mosse CA, Swain CP. Endoscopy without air insufflation. Gastrointest Endosc 2000. 51A260.
6. Lewis BS. The history of enteroscopy. Gastrointest Endosc Clin N Am 1999. 91–11.
7. Meron GD. The development of the swallowable video capsule (M2A). Gastrointest Endosc 2000. 52817–819.
8. Mosse CA, Swain CP. Technical advanced and experimental devices for enteroscopy. Gastrointest Endosc Clin N Am 1999. 9145–161.
9. Scapa E, Meron G, Glukhovsky A, Gat D, Jacob H, Shreiber R. Wireless capsule colonoscopy. Gastrointest Endosc 2001. 53A111.
10. Seidman EG. Wireless capsule video-endoscopy : an odyssey beyond the end of the scope. J Pediatr Gastroenterol Nutr 2002. 34333–334.
11. Gong F, Swain P, Mills T. Wireless endoscopy. Gastrointest Endosc 2000. 51725–729.
12. Swain CP, Gong F, Mills TN. Wireless transmission of a color television moving image from the stomach using a miniature CCD camera, light source and microwave transmitter. Gut 1996. 39A26.
13. Swain P. Wireless capsule endoscopy. Gut 2003. 52IV48–IV50.
14. Appleyard Glukhovsky A, Jacob H. Transit times for the capsule endoscope. Gastrointest Endosc 2001. 53A122.
15. Fischer D, Shreiber R, Meron G, Frisch M, Jacob H, Engel A, et al. Localization of the wireless capsule endoscopy in its passage through the GI tract. Gastrointest Endosc 2001. 53A126.
16. Seitz U, Bohnacker S, Soehendra N. A simple method to determine the location of the capsule and thus whether prokinetic drugs are needed during video capsule endoscopy. Endoscopy 2002. 341027.
17. Stiffler HL. Capsule endoscopy : a case study of an 11-year-old girl. Gastroenterol Nurs 2003. 2638–40.
18. Appleyard M, Blukhovsky A, Swain P. Wireless capusle endoscopy for recurrent small-bowel bleeding. N Engl J Med 2001. 344232–233.
19. Appleyard M, Fireman Z, Glukhovsky A, Jacob H, Shreiver R, Zaretsk A, et al. A randomized trial comparing wireless capsule endoscopy with push enteroscopy for the detection of small-bowel lesions. Gastroenterology 2000. 1191431–1438.
20. Costamagna G, Shah SK, Riccioni ME, Foschia F, Mutignani M, Marano P, et al. A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 2002. 123999–1005.
21. Ell C, Remke S, May A, Helou L, Henrich R, Mayer G. The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding. Endoscopy 2002. 34685–689.
22. Eliakim R, Fischer D, Suissa A, Yassin K, Katz D, Migdal M, et al. Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn's disease. Eur J Gastroenterol Hepatol 2003. 15363–367.
23. Lewis B, Goldforb N. The advent of capsule endoscopy-a not-so-futuristic approach to obscure gastrointestinal bleeding. Aliment Pharmacol Ther 2003. 11085–1096.
24. Lewis BS, Swain P. Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding : Results of a pilot study. Gastrointest Endosc 2002. 56349–353.
25. Scapa E, Jacob H, Lewkowicz S, Migdal M, Gat D, Fireman Z, et al. Initial experience of wireless-capsule endoscopy for evaluating occult gastrointestinal bleeding and suspected small bowel pathology. Am J Gastroenterol 2002. 972776–2779.
26. Van Gossum A. Capsule endoscopy in patients with obscure GI bleeding. Gastrointest Endosc 2003. 57629.
27. Waye JD. Small-bowel endoscopy. Endoscopy 2003. 3515. 21.
28. Zuckerman GR, Prakash C, Askin MP, Lewis BS. AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology 2000. 118201–221.
29. Faigel DO, Fennerty MB. Cutting the cord for capsule endoscopy. Gastroenterology 2002. 1231385–1388.
30. Fireman Z, Mahajna E, Broide E, Shapiro M, Fich L, Scapa E, et al. Diagnosing small bowel Crohn's disease with wireless capsule endoscopy. Gut 2003. 52390–392.
31. Ginsberg GG, Barkun AN, Bosco JJ, Isenberg GA, Nguyen CC, Taitelbaum G, et al. Wireless capsule endoscopy : August 2002. Gastrointest Endosc 2002. 56621–624.
32. Gonzalez-Suarez B, Guarner C, Escudero JR, Viver E, Palmer J, Balanzo J. Wireless capsule video endoscopy : a new diagnostic method for aortoduodenal fissure. Endoscopy 2002. 34938.
33. Mascarenhas-Saraiva M, Lopes L, Mascarenhas-Saraiva A. Watermelon stomach seen by wireless-capsule endoscopy. Endoscopy 2003. 35100.
34. Mylonaki M, MacLean D, Fritscher-Ravens A, Swain P. Wireless capsule endoscopic detection of Meckel's diverticulum after nondiagnostic surgery. Endoscopy 2002. 341018–1020.
35. Nageshwar Reddy D, Sriram PV, Rao GV, Bhaskar Reddy D. Capsule endoscopy appearances of small-bowel tuberculosis. Endoscopy 2003. 3599.
36. Sultan S, Dobozi BM, Palmer P, Treem WR, Agrawal NM. Assisted wireless capsule endoscopy in a six-year-old with abdominal pain and obscure GI bleeding. DDW 2003. M1725.
37. Lewkowicz S, Shreiber R, Jacob H, Gat D, Kraizer Y, Seligson B. Results of the 1st study of the safety, transit time and dynamics of the M2A patency capsule in healthy volunteers. DDW 2003. 491.

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Copyright © 2003 Korean Medical Association

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