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J Korean Med Assoc > Volume 60(6); 2017 > Article
Journal of the Korean Medical Association 2017;60(6):499-505.
Published online July 10, 2017.
DOI: https://doi.org/10.5124/jkma.2017.60.6.499   
Saphenous vein occlusion with cyanoacrylate: a systematic review
Seokang Chung, Jeong Su Park, Seok Hyun Kim
Division for New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. shkim@neca.re.kr
Saphenous vein occlusion with cyanoacrylate is a new technology for the treatment of incompetent veins by endovascular embolization with cyanoacrylate glue. The objective of this review was to evaluate the safety and effectiveness of saphenous vein occlusion with cyanoacrylate. A literature search was conducted using 8 Korean databases, Medline, Embase, and the Cochrane Library. From the 1,730 articles that were initially identified, 8 studies (1 randomized controlled trial, 1 non-randomized controlled trial, and 6 case series/case reports) were included in this review. The results show that similar levels of adverse events or complications occurred in patients treated with cyanoacrylate ablation compared to the other treatment groups (laser ablation or radiofrequency ablation), but the ecchymosis and closure rates of the treated veins were significantly better in the cyanoacrylate ablation group. Improvements in symptoms and quality of life after the treatment were also observed. On the basis of the current data, saphenous vein occlusion with cyanoacrylate can be recommended as a safe and effective treatment for patients with saphenous vein reflux.
Key Words: Cyanoacrylate, Saphenous vein, Varicose veins, Systematic review


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