Treatment of Acne
Article information
J Korean Med Assoc. 2006;49(1):63-69
Publication date (electronic) : 2006 January 31
doi :
https://doi.org/10.5124/jkma.2006.49.1.63
Abstract
Acne vulgaris is a self-limited disease, seen primarily in adolescents. Most cases of acne are pleomorphic, presenting various lesions consisting of comedones, pustules, and nodules. Although it has been traditionally classified as a disease of the sebaceous gland, it actually involves the pilosebaceous unit. There are four major principles in the treatment of acne: ① correct the altered pattern of follicular keratinization; ② decrease the sebaceous gland activity; ③ decrease the follicular bacterial population; and ④ produce anti-inflammatory effect. The natural course of acne varies greatly, and therefore, the determination of the therapeutic efficacy of medications for the treatment of acne is far from being simple.
Keywords: Acne; Pilosebaceous Unit; Comedone; Retinoid
References
2. Irwin MF, Arthur ZE. Fitzpatrick's dermatology 6th edth ed. New York: Mcgrawhill; 672–688.
3. Del Rosso JQ. Retinoic acid receptors and topical acne therapy. Cutis 2002. 70127–129.
4. Wolf JE. An update of recent clinical trials examining adapalene and acne. J Eur Acad Dermatol Venereol 2001. 15Suppl 3. S23–S29.
5. Kakita L. Tazarotene versus tretinoin or adapalene in the treatment of acne vulgaris. J Am Acad Dermatol 2000. 43S51–S54.
6. Menter A. Pharmacokinetics and safety of tazarotene. J Am Acad Dermatol 2000. 43S31–S35.
7. Millikan LE. Adapalene: an update on newer comparative studies between the various retinoids. Int J Dermatol 2000. 39784–788.
8. Leyden JJ. Current issues in antimicrobial therapy for the treatment of acne. J Eur Acad Dermatol Venereol 2001. 15Suppl 3. S51–S55.
9. Russell JJ. Topical therapy for acne. Am Family Physician 2000. 61357–366.
10. Berson DS, Shalita AR. The treatment of acne: the role of combination therapies. J Am Acad Dermatol 1995. 32S31–S41.
11. Webster G. Combination azelaic acid therapy for acne vulgaris. J Am Acad Dermatol 2000. 43S47–S50.
12. Plewig G, Kligman AM. Acne and rosacea 2000. 3rd edth ed. Berlin: Springer-Verlag; 649–680.
13. Cunliffe WJ, van de Kerkhof PC, Caputo R, Cavicchini S, Cooper A, Shaita A, et al. Roaccutane treatment guidelines: Results of an international survey. Dermatology 1997. 194351–357.
14. Wysowski DK, Swann J, Vega A. Use of isotretinoin (Accutane) in the united states: Rapid increase from 1992 through 2000. J Am Acad Dermatol 2002. 46505–509.
15. Goodman GJ. Management of post-acne scarring. What are the options for treatment? Am J Clin Dermatol 2000. 13–17.
16. Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol 2001. 45109–117.
17. Sawcer D, Lee HR, Lowe NJ. Lasers and adjunctive treatments for facial scars: a review. J Cutan Laser Ther 1999. 177–85.
18. Victor ER. Optical treatments for acne. Dermatologic therapy 2005. 18253–266.
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