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J Korean Med Assoc > Volume 61(11); 2018 > Article
Journal of the Korean Medical Association 2018;61(11):644-648.
Published online November 20, 2018.
DOI: https://doi.org/10.5124/jkma.2018.61.11.644   
Pathogenesis and prevention of skin cancer
Byung Ho Oh
Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. obh505@gmail.com
The incidence of skin cancer has continuously increased in Korea, probably due to sun exposure and increases in the aging population. Ultraviolet light, a well-known risk factor for skin cancer, can cause DNA damage, mutation, and immune suppression, followed by abnormal proliferation. To prevent photocarcinogenesis, the appropriate use of sunscreen should be emphasized. Using broad-spectrum sunscreens with sun protection factor values of 15 or higher and frequent reapplication are recommended. Controversy exists about whether vitamin D synthesis is inhibited by the use of sunscreen. However, considering that skin cancer most commonly develops on the head and neck area, applying it to the face and neck is reasonable in terms of balancing the risk-benefit ratio.
Key Words: Skin neoplasms, Ultraviolet rays, Sunscreening agents, Vitamin D


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