Recent Advances in the Treatment of Spondyloarthropathy

Dae-Hyun Yoo

doi:10.5124/jkma.2003.46.11.972

J Korean Med Assoc > Volume 46(11); 2003 > Article

Yoo: Recent Advances in the Treatment of Spondyloarthropathy

Special Issue I

Arthritis

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2003; 46(11): 972-980.

Published online: November 30, 2003

DOI: http://dx.doi.org/10.5124/jkma.2003.46.11.972

Recent Advances in the Treatment of Spondyloarthropathy

Dae-Hyun Yoo, M.D.

Department of Internal Medicine, Hanyang University College of Medicine & Hospital for Rheumatic Disease, Korea. dhyoo@hanyang.ac.kr

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Spondyloarthropathy is a chronic inflammatory disease involving axial joints and peripheral joints, and finally induces ankylosis of the spine. Treatment of spondyloarthropathy including ankylosing spondylitis has many limitations. Nonsteroidal anti-inflammatory drugs have played an important role in the control of pain and stiffness, however, could not inhibit the development of axial joint deformity. Although disease-modifying antirheumatic drugs, such as sulfasalazine, methotrexate, and cyclosporine, are currently used in the clinic, clinical data supporting their efficacy from randomized controlled studies are still not enough. Also the efficacy of pamidronate, thalidomide, or other potential therapeutic agents needs to be confirmed by randomized controlled trials. Lately the introduction of inhibitors of tumor necrosis factor alpha in the rheumatic diseases has made a great advance in the management of spondyloarthropathy. Here I review the conventional and newly introduced options in the management of spondyloarthropathy.

Ankylosing spondylitis; Psoriatic arthritis; DMARD; Pamidronate; Treatment; Tumor necrosis factor alpha

References

1. Braun J, van der Heijde D, Pincus T. Novel antirheumatic therapies challenge old views on ankylosing spondylitis and other spondyloarhtritides. Clin Exp Rheumatol 2002;20:Suppl 20. 1-2.

2. Braun J, Pham T, Sieper J, Davis J, van der Linden S, van der Heijde D, et al. ASAS Working Group. International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis 2003;62:817-824.

3. Pham T, van der Heijde D, Calin A, Khan MA, van der Linden S, Dougados M, et al. ASAS Working Group. Initiation of bio-logical agents in patients with ankylosing spondylitis : results of a Delphi study by the ASAS Group. Ann Rheum Dis 2003;62:812-816.

4. Maksymowych WP, Inman RD, Gladman D, Thomson G, Stone M, Russell AS, et al. Spondyloarthritis Research Consortium of Canada(SPARCC). Canadian Rheumatology Association Consensus on the use of anti-tumor necrosis factor-alpha directed therapies in the treatment of spondyloarthritis. J Rheumatol 2003;30:1356-1363.

5. Baeten D, Kruithof E, Van den Bosch F, Van den Bossche N, Herssens A, Veys EM, et al. Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab : a new perspective on the role of host defence in the pathogenesis of the disease? Ann Rheum Dis 2003;62:829-834.

6. Breban M, Vignon E, Claudepierre P, Devauchelle V, Wendling D, Dougados M, et al. Efficacy of infliximab in refractory ankylosing spondylitis : results of a six-month open-label study. Rheumatology 2002;41:1280-1285.

7. Braun J, Brandt J, Listing J, Zink A, Alten R, Sieper J, et al. Long-term efficacy and safety of infliximab in the treatment of ankylosing spondylitis : an open, observational, extension study of a three-month, randomized, placebo-controlled trial. Arthritis Rheum 2003;48:2224-2233.

8. Brandt J, Khariouzov A, Listing J, Haibel H, Sorensen H, Braun J, et al. Six-month results of a double-blind, placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis. Arthritis Rheum 2003;48:1667-1675.

9. Braun J, Sieper J. Therapy of ankylosing spondylitis and other spondyloarthritides : established medical treatment, anti-TNF-alpha therapy and other novel approaches. Arthritis Res 2002;4:307-321.

10. van der Horst-Bruinsma IE, Clegg DO, Dijkmans BA. Treatment of ankylosing spondylitis with disease modifying antirheumatic drugs. Clin Exp Rheumatol 2002;20:Suppl 28. S67-S70.

11. Miceli-Richard C, Dougados M. NSAIDs in ankylosing spondylitis. Clin Exp Rheumatol 2002;20:Suppl 28. S65-S66.

12. Dougados M, Dijkmans B, Khan M, Maksymowych W, van der Linden S, Brandt J. Conventional treatments for ankylosing spondylitis. Ann Rheum Dis 2002;61:Suppl 3. 40-50.

13. Roychowdhury B, Bintley-Bagot S, Bulgen DY, Thompson RN, Tunn EJ, Moots RJ. Is methotrexate effective in ankylosing spondylitis? Rheumatology 2002;41:1330-1332.

14. Zou JX, Braun J, Sieper J. Immunological basis for the use of TNF alpha-blocking agents in ankylosing spondylitis and immunological changes during treatment. Clin Exp Rheumatol 2002;20:Suppl 28. S34-S37.

15. Braun J, Baraliakos X, Golder W, Brandt J, Rudwaleit M, Van Der Heijde D, et al. Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis, before and after successful therapy with infliximab : evaluation of a new scoring system. Arthritis Rheum 2003;48:1126-1136.

16. Rosenbaum JT, Smith JR. Anti-TNF therapy for eye involvement in spondyloarthropathy. Clin Exp Rheumatol 2002;20:Suppl 28. S143-S145.

17. Davis JC Jr, Huang F, Maksymowych W. New therapies for ankylosing spondylitis : etanercept, thalidomide, and pamidronate. Rheum Dis Clin North Am 2003;29:481-494.

18. Haibel H, Braun J, Maksymowych WP. Bisphosphonates-targeting bone in the treatment of spondyloarthritis. Clin Exp Rheumatol 2002;20:Suppl 28. S162-S166.

19. Maksymowych WP, Jhangri GS, Fitzgerald AA, LeClercq S, Chiu P, Russell AS, et al. A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate(60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis. Arthritis Rheum 2002;446:766-773.

20. Haibel H, Brandt J, Rudwaleit M, Soerensen H, Sieper J, Braun J. Treatment of ankylosing spondylitis with pamidronate. Rheumatology 2003;42:1018-1020.

21. Ossandon A, Cassara EA, Priori R, Valesini G. Thalidomide : focus on its employment in rheumatologic diseases. Clin Exp Rheumatol 2002;20:709-718.

22. Huang F, Wei JC, Breban M. Thalidomide in ankylosing spondylitis. Clin Exp Rheumatol 2002;20:Suppl 28. S158-S161.

23. Huang F, Gu J, Zhao W, Zhu J, Zhang J, Yu DT. One-year open-label trial of thalidomide in ankylosing spondylitis. Arthritis Rheum 2002;47:249-254.

24. Pipitone N, Kingsley GH, Manzo A, Scott DL, Pitzalis C. Current concepts and new developments in the treatment of psoriatic arthritis. Rheumatology 2003;42:1138-1148.

25. Salvarani C, Cantini F, Olivieri I. Disease-modifying antirheumatic drug therapy for psoriatic arthritis. Clin Exp Rheumatol 2002;20:Suppl 28. S71-S75.

26. Sarzi-Puttini P, Santandrea S, Boccassini L, Panni B, Caruso I. The role of NSAIDs in psoriatic arthritis : evidence from a controlled study with nimesulide. Clin Exp Rheumatol 2001;19:Suppl 22. S17-S20.

27. Salvarani C, Cantini F, Olivieri I, Macchioni P, Padula A, Boiardi L, et al. Efficacy of infliximab in resistant psoriatic arthritis. Arthritis Rheum 2003;49:541-545.

28. Weinberg JM, Saini R, Tutrone WD. Biologic therapy for psoriasis-the first wave : infliximab, etanercept, efalizumab, and alefacept. J Drugs Dermatol 2002;1:303-310.