Treatment of Psoriasis

Jai-Il Youn

doi:10.5124/jkma.2006.49.2.150

J Korean Med Assoc > Volume 49(2); 2006 > Article

Youn: Treatment of Psoriasis

Continuing Education Column

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2006; 49(2): 150-160.

Published online: February 28, 2006

DOI: http://dx.doi.org/10.5124/jkma.2006.49.2.150

Treatment of Psoriasis

Jai-Il Youn, M.D.

Department of Dermatology, Seoul National University College of Medicine & Hospital, Korea. jaiil@snu.ac.kr

Abstract

Psoriasis is a common, chronic skin disease. The goal of therapy is always to use the appropriate medication to achieve the desired effect while minimizing side effect. The three types of traditional therapies for treatment of psoriasis are topical therapies, phototherapies and systemic therapies. Topical steroid, vit D derivatives are frequently prescribed with other agents. Broad band UVB, PUVA and narrow band UVB therapies are most commonly used phototherapy. Three main systemic agents now used for moderate to severe psoriasis are retinoid, cyclosporine and methotrexate. Psoriasis is recently found to be an T-cell mediated immunologic disease. This lead to the developing new targeted immunobiologic agents.The newer biologic agents appear to combine greater efficacy of treatments with less toxicity by targeting T cell activation or specific mediator, TNF-α

Psoriasis; Phototherapy; Retinoid; Cyclosporine; Biologics

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