Pharmacological Therapy in Osteoarthritis

Yeong Wook Song

doi:10.5124/jkma.2003.46.11.958

J Korean Med Assoc > Volume 46(11); 2003 > Article

Song: Pharmacological Therapy in Osteoarthritis

Special Issue I

Arthritis

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2003; 46(11): 958-964.

Published online: November 30, 2003

DOI: https://doi.org/10.5124/jkma.2003.46.11.958

Pharmacological Therapy in Osteoarthritis

Yeong Wook Song, M.D.

Department of Internal Medicine, Seoul National University College of Medicine & Hospital, Korea. ysong@snu.ac.kr

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoarthritis (OA) is a common, chronic, and painful disorder characterized by cartilage loss. It is the most common among all rheumatic disorders and is a major cause of disability. OA can be managed with a variety of pharmacological therapies, including acetaminophen, traditional nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors, intra-articular steroids, viscosupplements, glucosamine, chondroitin sulfate, and capsaicin. In this review, I describe the clinical efficacy and side effects of these pharmaceuticals and review disease-modifying osteoarthritis drugs (DMOAD), such as glucosamine, diacerein, and avocado/soybean unsaponifiables, of which the clinical efficacy still remains to be determined.

Keywords: Osteoarthritis; Acetaminophen; Nonsteroidal anti-inflammatory drug; Disease modifying osteoarthritis drug

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Pharmacological Therapy in Osteoarthritis

Abstract

References

Figure 1